White lines have been painted on the pavement and yellow signs put up at Royal Derby Hospital to help visually-impaired patients.
Staff said people with sight problems would be able to use them to help them find their way to the eye clinics independently.
The work has been carried out with the help of charity Sight Support Derbyshire and after speaking with people who use the clinics at Kings Treatment Centre.
It includes a white-painted line, with eye symbols, running from the main entrance and past the bus stop – which most patients use to reach the centre – and moving all signs for the clinic to eye level and colouring them in bright yellow. Inside the centre, there is also a yellow line running down the left side on the way to the clinics.
Staff say obstacles have been removed or have painted bands around them.
Howard Birchall, 67, has been visually-impaired for 16 years. He said: "It is important to highlight that so many people with sight loss will be supported by these changes."
Source: This is Derbyshire